Students use a simulated blood typing kit to identify the ABO and Rh blood groups of synthetic blood samples. The activity demonstrates how agglutination reactions work in real blood typing while remaining completely safe.

1. Purchase and use a simulated blood typing kit.
2. Follow the kit instructions to test synthetic blood samples with synthetic anti-A, anti-B, and anti-Rh sera.
3. Observe the agglutination (clumping) reactions to determine each blood type.
4. Record the blood types for each of the provided samples.

Blood Typing Lab Demo - Maria Berger:

Blood Typing Demonstration Using Simulated Blood - ProfJWagner:

• Have students predict the blood type before testing and compare with actual results.
• Use the results to set up a mock forensic investigation or paternity test scenario.
• Combine with lessons on blood transfusion compatibility.

• No actual blood is used; the kit is safe for classroom use.
• Handle all reagents and glass/plastic labware carefully to avoid spills.
• Clean workspaces thoroughly after the experiment.

• What causes agglutination during a blood typing test? (Antibodies in the sera bind to specific antigens on red blood cells.)
• Why is knowing blood type important in medicine? (It ensures safe blood transfusions and avoids dangerous immune reactions.)
• How can blood typing be used in forensics? (It helps exclude or narrow down suspects by comparing blood evidence with known samples.)
• What percentage of the population has each blood type? (Varies by region.)